Case Report

Spontaneous bleeding in a neonatal calf persistently infected with BVDV1b

  • J. Laureyns
  • B. Pardon
  • A. B. Caij
  • S. Sarrazin
  • P. Deprez


A calf developed skin bleeding on the second day of its life. It was referred to the clinic onsuspicion of bovine neonatal pancytopenia (BNP). Hematology showed extreme thrombocytopenia,moderate anemia, but no leukopenia. A PCR test on a heparinized blood sample was bovine viraldiarrhea virus (BVDV) positive, as were the two BVDV antigen ELISAs performed three and tenweeks later. Non-cytopathic BVDV type 1b was isolated from the blood. Although the calf recoveredfrom hemorrhagic disease, and continued to be healthy, it was euthanized at eleven weeks of agebecause of persistent BVDV infection. On the basis of the case history, BNP could be excludedfrom the differential diagnosis. This case illustrates that hemorrhagic disease is not exclusivelyassociated with BVDV type 2 and that the clinical signs in neonatal calves infected with BVDV1bcan be identical to the clinical presentation of BNP.

How to Cite:

Laureyns, J. & Pardon, B. & Caij, A. & Sarrazin, S. & Deprez, P., (2013) “Spontaneous bleeding in a neonatal calf persistently infected with BVDV1b”, Vlaams Diergeneeskundig Tijdschrift 82(2), 87-90. doi:

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Published on
29 Apr 2013
Peer Reviewed