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Subaortic stenosis in the Newfoundland: heredity, pathophysiology, diagnosis, prognosis and breeding advice

Authors
  • K. Caestecker
  • L. Peelman
  • V. Bavegems

Abstract

Subaortic stenosis is a narrowing of the left ventricular outflow tract just below the aortic valve, and is one of the most diagnosed congenital inherited heart diseases in the Newfoundland. The classification of subaortic stenosis is based on the lesions or the findings on echocardiography. Although the mode of inheritance is uncertain, a dominant trait with variable penetrance is generally accepted. The Epidermal Growth Factor Receptor oncogene is, together with the Ptpn11-gene, a possible candidate gene to be involved in this disease. The diagnosis is particulary based on auscultation and echocardiography. The prognosis is variable and breeding advice is based on echocardiographic screening at the age of eighteen months; however, it remains a difficult issue.

How to Cite:

Caestecker, K. & Peelman, L. & Bavegems, V., (2012) “Subaortic stenosis in the Newfoundland: heredity, pathophysiology, diagnosis, prognosis and breeding advice”, Vlaams Diergeneeskundig Tijdschrift 81(3), 138-148. doi: https://doi.org/10.21825/vdt.v81i3.18350

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Published on
28 Jun 2012
Peer Reviewed